Canonical: https://echosuite.app/guides/lv-gls/

# Global longitudinal strain calculator: LV GLS and serial change

Review left ventricular global longitudinal strain and serial-change inputs, with the tool’s measurement and source context.

Created by [Mohammed Kamareddine, MD](https://echosuite.app/about/) · [Sources & educational scope](https://echosuite.app/about/)

[Open interactive calculator →](https://echosuite.app/calculators/#lv-gls)

## Method

Relative reduction = (|baseline GLS| − |follow-up GLS|) ÷ |baseline GLS| × 100

Use the measurement units shown below. Some fields apply only to a selected method or condition; follow the interactive tool’s method choices. The interactive tool keeps missing measurements incomplete and provides its method-specific results and reference context.

## Measurements and acquisition

### Current GLS · signed  %

Enter the measured value in the displayed unit

- Confirm the variable matches the selected formula.
- Use the unit displayed beside the field.
- Keep measurements from the same representative hemodynamic state.

### Baseline GLS · signed  %

Enter the measured value in the displayed unit · Optional

- Confirm the variable matches the selected formula.
- Use the unit displayed beside the field.
- Keep measurements from the same representative hemodynamic state.

## Sources and method context

ASE / EACVI · 2025 · Clinical Applications of Strain Echocardiography · Global reference ranges and serial comparison pp.994–995

[Primary reference](https://www.asecho.org/wp-content/uploads/2025/11/Strain-2025-Guideline-2.pdf)

- Acquisition and interpretation · Global reference ranges and serial comparison pp.994–995

Method-specific acquisition and reference context. Arithmetic uses entered measurements; clinical interpretation remains subject to image quality and study context.

Catalogue review status: Exact guideline locator mapped · clinical sign-off pending

These pages describe the educational tool. Interpret measurements with the complete clinical context and the method’s acquisition limitations.

## Keep exploring

- [Apical four chamber acquisition guide](https://echosuite.app/guides/views/apical-four-chamber/) · [Open in Probe Lab](https://echosuite.app/#a4c)
- [Apical two chamber acquisition guide](https://echosuite.app/guides/views/apical-two-chamber/) · [Open in Probe Lab](https://echosuite.app/#a2c)
- [Apical three chamber (apical long axis) acquisition guide](https://echosuite.app/guides/views/apical-three-chamber/) · [Open in Probe Lab](https://echosuite.app/#a3c)
- [Left ventricular fractional shortening calculator](https://echosuite.app/guides/fractional-shortening/)
- [Left ventricular dimensions calculator and measurement guide](https://echosuite.app/guides/lv-linear/)
- [Left ventricular mass and wall thickness calculator](https://echosuite.app/guides/lv-mass/)
- [Left ventricular volume index calculator: EDV and ESV](https://echosuite.app/guides/lv-volume-index/)

[All echo guides](https://echosuite.app/guides/) · [Learning paths](https://echosuite.app/learn/)